Extensión tumoral intraoperatoria radioguiada en cáncer gastrointestinal con alta expresión de receptor del factor de crecimiento epidérmico
Abstract
Con el auge contemporáneo de novedosos paradigmas en las ciencias médicas, como la Medicina Personalizada, se busca una resección oncológica más eficaz: con nuevos márgenes quirúrgicos de acuerdo al estadio tumoral. Para alcanzar estos resultados, se abren paso técnicas como la cirugía radioinmunoguiada. En Cuba los adelantos biotecnológicos han permitido eldesarrollo de fármacos líderes en el mundo, como el Nimotuzumab, un anticuerpo monoclonal dirigido contra el receptor del factor de crecimiento epidérmico, sobrexpresado en múltiples tumores malignos de origen epitelial. Al marcarlo con un radioisótopo puede auxiliar al cirujano en la determinación precisa de la extensión tumoral (radioguiada) de estas neoplasias durante el acto quirúrgico.
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