Cognitive impairment and degree of dependence in patients with mild to moderate Alzheimer's disease

Authors

Keywords:

cognitive impairment, Alzheimer's disease, degree of dependency

Abstract

Introduction: Alzheimer's disease is a chronic and progressive neurodegenerative disease that affects the brain. As the disease progresses, symptoms worsen and can include memory loss, disorientation, mood swings, difficulty performing daily activities, sleep disturbances, and loss of the ability to make appropriate judgments and decisions.

Objective: To determine the relationship between cognitive decline and the degree of dependence in patients with mild to moderate Alzheimer's disease.

Method: A cross-sectional, descriptive, observational study was conducted. The sample consisted of all patients with mild-to-moderate Alzheimer's disease treated at International Center for Neurological Restoration from January to July 2023. The sample selected by probability sampling consisted of 30 patients diagnosed with mild-to-moderate Alzheimer's disease. The sociodemographic variables were age, education, sex, and race, as well as the degree of dependence and cognitive impairment. Cognitive functions and the degree of dependence were assessed using neuropsychological profile instruments.

Results: All patients showed some degree of cognitive impairment, with very mild and mild predominating, with varying degrees of functional capacity. Thirteen of the patients evaluated showed complete independence, while the rest showed a high degree of dependence.

Conclusions: There is an inverse correlation between both variables in the selected sample; this seems to indicate that a greater degree of cognitive impairment is related to a lower degree of functional independence.

References

1. Becerra J. Deterioro cognitivo y su influencia en la calidad de vida del adulto mayor. Ecuador: Universidad Técnica de Ambato. 2017.

2. Bautista LM. Deterioro cognitivo y autocuidado en el adulto mayor atendido en el puesto de salud cuyumalca – chota, 2021. Universidad Nacional de Cajamarca, Perú. Tesis de Licenciatura en Enfermería [Internet]. 2022 [acceso: 12/06/2025]. Disponible en: https://repositorio.unc.edu.pe/bitstream/handle/20.500.14074/4748/TESISSSS%20FINALLLLLLLLLLLLLLLLLL%20%282%29.pdf?sequence=1&isAllowed=y

3. Alvares M, Ávila C. Deterioro cognitivo y actividades de la vida diaria en adultos mayores del centro geriátrico hogar Cristo Rey. Cuenca, Ecuador. Trabajo de graduación [Internet]. 2022 [acceso: 12/06/2025]. Disponible en: http://dspace.uazuay.edu.ec/handle/datos/11603

4. Jiménez Aguilera B, Baillet Esquivel LE, Ávalos Pérez F, Campos Aragón L. Dependencia funcional y percepción de apoyo familiar en el adulto mayor. Aten Fam [Internet]. 2016;23(4):129-133.DOI: https://doi.org/10.1016/j.af.2016.08.002

5. Arroyo RA. Relación de las actividades básicas de la vida diaria en adultos con y sin deterioro cognitivo leve. Universidad privada Antenor Orrego, Perú. Tesis de grado [Internet]. 2021 [acceso: 12/06/2025]. Disponible en: https://hdl.handle.net/20.500.12759/7607

6. Novo Lima AM, Ferreira da Silva Martins MM, Martins Ferreira MS, Fernández Carla S, Dornelles Schoeller S, Oliveira Parola VS. Del concepto de independencia al cuestionamiento de su uso en la práctica: scoping review. Enferm glob. [Internet]. 2022 [acceso: 08/02/2026]; 21(6): 625-654. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1695-61412022000100625&lng=es

7. Pérez Ruiz L, Rodríguez Obaya T, Sosa Pérez S, Urrutia Amable N, González Dalmau E, Fernández Nin A, et al. NeuroEPO plus (NeuralCIM®) en el síndrome clínico Alzheimer leve-moderado: ensayo clínico aleatorizado ATHENEA. Anales de la Academia de Ciencias de Cuba [Internet]. 2024 [acceso: 12/06/2025]; 4(3):1-15. Disponible en: http://scielo.sld.cu/pdf/aacc/v14n3/2304-0106-aacc-14-03-e1630.pdf

8. Díaz Canel Bermudez M. Comienza hoy ensayo clínico de novedoso medicamento para el tratamiento del Alzheimer leve o moderado. Período Granma. 2023. Disponible en: https://www.Granma .cu/file/pdf/2023/02/27/G_2023022704.pdf

9. Nepsa. Escala de Deterioro Global [Internet]. 2021 [acceso: 12/06/2025]. Disponible en: https://nepsa.es/ escala-de-deterioro-global/

10. Tafiadis D, Siafaka V, Voniati L, Prentza A, Papadopoulos A, Ziavra N, et al. . Actividades instrumentales de la vida diaria de Lawton para adultos de habla griega con deterioro cognitivo: un estudio de evaluación psicométrica con análisis adicional de la curva característica operativa del receptor. Ciencia del cerebro [Internet]. 2023 [acceso: 12/06/2025]; 13 (7): 1093. Disponible en: https://pmc-ncbi-nlm-nihgov.translate.goog/articles/PMC10377235/?_x_ tr_sl=en&_x_tr_tl=es&_x_tr_hl=es&_x_tr_pto=tc

11. Marines L, Daniani C, Rosane K, Hildebrandt LR. Capacidad funcional y nivel cognitivo de adultos mayores residentes en una comunidad en el sur de Brasil. Enferm. Glob [Internet]. 2015 [acceso: 12/06/2025]; 14(37): 1-11. Disponible en: https://www.redalyc.org/pdf/3658/365834856001.pdf

12. Fernández W. Capacidad funcional y deterioro cognitivo en pacientes adultos mayores que acuden al consultorio de geriatría del hospital Sergio E. Bernales Comas. Lima, Perú: Universidad César Vallejos. Tesis de grado [Internet]. 2019 [acceso: 12/06/2025]. Disponible en: https://hdl.handle.net/20.500.12692/60641

Published

2026-02-24

How to Cite

1.
Cabrera Abreu I, Casabona Fernández E, Ricardo de la Fe Y, Llinar Castillo S, Pavon Fuentes N, Morgado Vega T, et al. Cognitive impairment and degree of dependence in patients with mild to moderate Alzheimer’s disease. Invest Medicoquir [Internet]. 2026 Feb. 24 [cited 2026 Feb. 26];18(1):e1006. Available from: https://revcimeq.sld.cu/index.php/imq/article/view/1006

Issue

Section

Research article