Surveillance of ventilator-associated events in intensive care units
Keywords:
ventilator-associated pneumonia, infection control, healthcare associated infectionsAbstract
Introduction: Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in adult intensive care units (ICU) worldwide. Diagnosis using conventional criteria (clinical, imaging, microbiological) can generate significant interobserver variability. In order to have a tool for monitoring VAP based on objective variables, in 2013 the United States Centers for Disease Control and Prevention (CDC) established the ventilator-associated event (VAE). However, the application of the method still shows controversial results to date.
Objectives: To describe the results of the implementation of VAE surveillance and to assess the correlation with traditional VAP surveillance, according to conventional criteria, in adult ICU in Cuba.
Method: National multicenter prospective cohort study. Sample: 150 patients admitted to 12 adult ICUs, who required invasive mechanical artificial ventilation for more than 48 hours. Surveillance was performed according to conventional and VAE criteria.
Results: Of a total of 37 patients reported with VAP by conventional criteria, 28 of them (75.7%) agreed with VAP likely according to CDC (Kappa: 0.756, p ˂ 0.001). Patients with possible VAP criteria (CDC) had significantly higher mortality (68.8%, p=0.04).
Conclusions: Surveillance of VAE is an objective method for the early detection of VAP that can also contribute to the homogenization of hospital epidemiological reports.
References
1. Howroyd F, Chacko C, MacDuff A, Gautam N, Pouchet B, Tunnicliffe B, et al. Ventilator-associated pneumonia: pathobiological heterogeneity and diagnostic challenges. Nat Commun. 2024 Jul 31;15(1):6447. doi: 10.1038/s41467-024-50805-z.
2. de Almeida MCS, Medeiros EAS, Agena F, Oliveira CC, Swawamura MVY, Costa SF, Carmona MJC, de Sa Malbouisson LM, Ventilator-associated events as a quality indicator in intensive care units, Journal of Hospital Infection. 2018 Volume 99, ISSUE 1, May 01, P104-105. doi: 10.1016/j.jhin.2018.02.010.
3. Klompas M (2007) Does this patient have ventilator‑associated pneumonia? JAMA 297:1583–1593
4. Serrano-Mayorga CC, Reyes LF. Ventilator-Associated Pneumonia: Bridging Global Disparities Through Standardized Definitions and Transparent Reporting. Chest. 2025 Jun;167(6):1517-1519. doi: 10.1016/j.chest.2025.02.005.
5. Klompas M. Interobserver variability in ventilator-associated pneumonia surveillance. Am J Infect Control. 2010 Apr;38(3):237-9. doi: 10.1016/j.ajic.2009.10.003.
6. Klompas M. What can we learn from international ventilator-associated pneumonia rates?. Crit Care Med. 2012 Dec;40(12):3303-4. doi: 10.1097/CCM.0b013e31826bf3a5.
7. Centers for Disease Control and Prevention: Ventilator-associated event protocol. Available at: http://www.cdc.gov/nhsn/acute-carehospital/vae/. Accessed April 16, 2014
8. Fan Y, Gao F, Wu Y, Zhang J, Zhu M, Xiong L. Does ventilator-associated event surveillance detect ventilator-associated pneumonia in intensive care units? A systematic review and meta-analysis. Crit Care. 2016 Oct 24;20(1):338.
9. Iosifidis E, Coffin S. Ventilator-associated Events in Children: Controversies and Research Needs. Pediatr Infect Dis J. 2020 Apr;39(4):e37-e39. doi: 10.1097/INF.0000000000002576.
10. Sesma AC, Francisetti VA, Pintado S, Paiva C, Mangiaterra SM. Valor diagnóstico del método semi-cuantitativo en el procesamiento de aspirados traqueales. Acta Bioquím Clín Latinoam 2012; 46 (3): 413-8
11. Ego A, Preiser JC, Vincent JL. Impact of diagnostic criteria on the incidence of ventilator-associated pneumonia. Chest. 2015 Feb;147(2):347-355. doi: 10.1378/chest.14-0610.
12. Pouly O, Lecailtel S, Six S, Préau S, Wallet F, Nseir S, et al. Accuracy of ventilator-associated events for the diagnosis of ventilator-associated lower respiratory tract infections. Ann Intensive Care. 2020 Jan 13;10(1):6. doi: 10.1186/s13613-020-0624-6.
13. Djuric O, Markovic-Denic L, Jovanovic B, Bumbasirevic V. Agreement between CDC/NHSN surveillance definitions and ECDC criteria in diagnosis of healthcare-associated infections in Serbian trauma patients. PLoS One. 2018 Oct 4;13(10):e0204893. doi: 10.1371/journal.pone.0204893.
14. Hidetsugu Kobayashi, Shigehiko Uchino, Masanori Takinami and Shoichi Uezono. The Impact of Ventilator-Associated Events in Critically Ill Subjects With Prolonged Mechanical Ventilation. Respiratory Care November 2017, 62 (11) 1379-1386; DOI: https://doi.org/10.4187/respcare.05073
15. Craven TH, Wojcik G, McCoubrey J, Brooks O, Grant E, Keating S, et al. Ventilator-associated pneumonia surveillance using two methods. J Hosp Infect. 2020 Apr;104(4):522-528. doi: 10.1016/j.jhin.2020.01.020.
16. Ramirez-Estrada S, Peña-Lopez Y, Kalwaje Eshwara V, Rello J. Ventilator-associated events versus ventilator-associated respiratory infections-moving into a new paradigm or merging both concepts, instead? Ann Transl Med. 2018 Nov;6(21):425. doi: 10.21037/atm.2018.10.54.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Anselmo A. Abdo Cuza, y colectivo de autores

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The authors retain copyright and all unrestricted publication rights.
Medicoquirúrgicas Research is licensed under the Creative Commons Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0) and follows the SciELO Publishing Schema (SciELO PS) for publishing in XML format.
You are free to:
- Share — copy and redistribute the material in any medium or format.
- Adapt — remix, transform, and build upon the material.
The license cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do this in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Non-Commercial — You may not use the material for commercial purposes.
No Additional Restrictions — You may not apply legal terms or technological measures that legally restrict others from making any use permitted by the license.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where their use is permitted by an applicable exception or limitation.
No warranties are given. The license may not give you all the permissions you need for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
